Rab GGTase is “responsible for the largest number of individual protein prenylation events in the cell,” probably due to this ability to interact with many different Rab proteins (it can prenylate any sequence containing a cysteine residue).In vitro studies have shown that https://www.moncleroutletssale.com Rab GGTase can be inhibited by nitrogen containing bisphosphonate drugs such as risedronate; however, the effects of such drugs seem to be much more limited in vivo (Coxon).RabGGTase is a heterodimer composed of alpha and beta subunits that are encoded by the RABGGTA and RABGGTB genes, respectively. The structure of rat RabGGTase has been determined by X ray diffraction (see image to the left) to a resolution of 1.80. RabGGTase’s secondary structure is largely composed of alpha helices; the alpha subunit is 74% helical with no beta sheets, while the beta subunit is 51% helical and 5% beta sheet. There are 28 alpha helices total (15 in the alpha subunit and 13 in the beta subunit) and 15 very short (no more than 4 residues) beta sheets.
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