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Rab GGTase is “responsible for the largest number of individual protein prenylation events in the cell,”[1] probably due to this ability to interact with many different Rab proteins (it can prenylate any sequence containing a cysteine residue).In vitro studies have shown that https://www.moncleroutletssale.com Rab GGTase can be inhibited by nitrogen containing bisphosphonate drugs such as risedronate; however, the effects of such drugs seem to be much more limited in vivo (Coxon).RabGGTase is a heterodimer composed of alpha and beta subunits that are encoded by the RABGGTA and RABGGTB genes, respectively. The structure of rat RabGGTase has been determined by X ray diffraction (see image to the left) to a resolution of 1.80.[1] RabGGTase’s secondary structure is largely composed of alpha helices; the alpha subunit is 74% helical with no beta sheets, while the beta subunit is 51% helical and 5% beta sheet. There are 28 alpha helices total (15 in the alpha subunit and 13 in the beta subunit) and 15 very short (no more than 4 residues) beta sheets.

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